02 May Stem Cell Therapy for Treatment of Liver Disease
According to statistics more than 130, 000 deaths from liver cirrhosis have occurred in the United States since 2017, with alcohol-related cirrhosis accounting for 70, 000 of these deaths. Stem cell therapy for the treatment of liver disease is now the alternative to regular treatments like liver transplants or lifestyle changes.
Long before now, liver transplants have been the go-to option for treatment. However, it always poses different problems for patients, the most prominent ones being the lack of donors and the potential for organ rejection and autoimmune hepatitis in the transplanted recipient. Although research in this regard is still ongoing, stem cells show incredible promise for liver disease treatment.
The liver is a very important organ of the body and is instrumental to the normal functioning of the body. Our liver helps with the digestion and metabolism of fatty food, and detoxification of drugs and toxins. The liver also synthesizes plasma protein and stores vitamins and minerals that are essential for the body.
Stem cells used for the treatment of liver disease can be obtained from different sources in the body to create Induced pluripotent stem cells (IPSCs) or mesenchymal stem cells (MSCs) that can be used to treat liver disease.
Stem Cells for Liver Diseases
Stem cell therapy is currently considered one of the safest and most efficient methods of treatment, particularly in liver disease treatment. The reason why it’s considered a safe method is that there’s a slim chance of rejection of the freshly introduced cells or other forms of side effects in the patient.
Stem cell therapy is founded on the model of regeneration of hepatocytes and other useful cells that can be utilized to help repair the damaged cells in the liver and other affected organs. The newly generated cells team up with the other cells and encourage the normal functioning of the liver organ of the body.
The stem cells are a natural part of the body, and they have the medical ability to not only help repair the damaged tissues but also replace those that aren’t functioning properly. After a stem cell therapy session, the patient will experience gradual improvements and changes in the body and isn’t at risk of self-rejection of the cells because the cells come from the umbilical cord.
Advantages and limitations of stem cell-based therapy for liver disease
Stem cell therapy for the treatment of liver diseases has many advantages. However, there are some other conditions you should consider. Some of the advantages include;
- Healthier treatment
- Ethical responsible treatment
- Decreased bleeding time
- Faster treatment and recovery
- Decreased chances of organ rejection and autoimmune hepatitis
Some other factors that you need to consider when you’re considering stem cell therapy for liver disease are:
- The long-term side effects of the therapy are yet to be determined.
- The cells of a particular origin would generate cells only of that type. As a result, brain cells would only generate cells for the brain.
Like a lot of the new concepts in regenerative medicine today, stem cell therapy is still undergoing proper research and some things require proper establishment.
Regenerative Potential of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells significantly reduce inflammatory factor secretion, immune cell infiltration, and hepatocyte apoptosis (also referred to as liver cell death) and up-regulate the antioxidant levels and energy metabolism in acute liver injuries.
Mesenchymal stem cells derived from the bone marrow will not only effectively rescue experimental liver failure, but also contribute to liver regeneration. It can also be a potential alternative therapy to organ transplantation for the treatment of liver diseases.
There is increasing evidence to suggest the bone marrow is a transplantable source of hepatic progenitors. And because multipotent bone marrow-derived mesenchymal stem cells can differentiate into functional hepatocyte-like cells with almost 100% induction frequency under defined conditions, the chances of this type of stem cell therapy being an effective treatment for liver diseases is very high.
Chronic liver disease causes serious damage to the liver that it can no longer repair itself. This can become dangerous and life-threatening. Damage to the liver over an extended period can lead to scar tissue that limits the ability of the organ to function properly. However, our medical professionals can make use of umbilical cord stem cell therapy to regenerate new liver cells that can be used to treat different types of liver diseases and prevent future ones from occurring.
Make an appointment with the best stem cell therapy clinic in the Los Angeles area today to start the conversation on how stem cell therapy may be the right treatment option for your liver condition.