Mesenchymal Stem Cell Therapy for Liver Disease

Mesenchymal Stem Cell Therapy for Liver Disease

Over the last few years, liver disease has fast become a prevalent disease with an increasing incidence across the United States. It has also become an upsetting cause of death and continues to increase as the years go by. Currently, it accounts for over 33,500 deaths yearly in the United States. Although there have always been different treatments for this disease, they’ve all had different issues.

For one, most of these treatments are either rarely available or too expensive for these patients. Also, there’s also the issue of coming with large costs of quality of life for those that need them. However, as technology and research advances, the introduction of stem cell treatments has created a new path toward recovering their health for people with liver disease.

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Stem cell therapy for Liver Diseases

Different studies through recent years have shown that Mesenchymal stem cells play an essential role in liver regrowth. This type of therapy is very effective and safe for liver-related diseases. As time goes by, stem cell-based therapies will maintain their stand as an effective treatment strategy for liver diseases and introduce a more viable option for patients in need.

One reason why stem cell therapy is a viable option is that stem cells have many properties ranging from immunomodulation, differentiation, and the ability to repair damaged tissues, all of which can be beneficial for liver disease.

The indications of cirrhosis of the liver are simply internal scarring and subsequent dysfunction of the liver. This condition can be caused by a number of factors, but the most prominent is the result of alcohol consumption, viral hepatitis B or C, and any other metabolic disorders.

Before now, the seemingly effective solution to this was a liver transplant. However, the procedure encounters a number of problems – from it being extremely expensive, to finding it hard to get willing donors, and the risk of rejection of the organ by the patient’s body.

For this reason, Mesenchymal stem cell therapy may be used as an alternative treatment option.

Anti-inflammatory properties of mesenchymal stem cells (MSCs)

Mesenchymal stem cells significantly reduce inflammatory factor secretion, immune cell infiltration, and hepatocyte apoptosis (also called liver cell death) and up-regulate the antioxidants levels and energy metabolism in acute liver injuries.

Mesenchymal stem cells derived from the bone marrow will not only effectively rescue experimental liver failure, but also contribute to liver regeneration. It can also be a potential alternative therapy to organ transplantation for the treatment of liver diseases.

There is increasing evidence to suggest the bone marrow is a transplantable source of hepatic progenitors. And because multipotent bone marrow-derived mesenchymal stem cells can differentiate into functional hepatocyte-like cells with almost 100% induction frequency under defined conditions, the chances of this type of stem cell therapy being an effective treatment for liver diseases is very high.

Make an appointment with the Advanced Stem Cell Institute today to meet with the best stem cell doctors in Los Angeles.

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